Monday, October 8, 2012

Gas chromatography vs Liquid chromatography

Gas Chromatography and Liquid Chromatography are two of the most common techniques used in most Analytical Chemistry Labs.

Gas chromatography (GC), is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.

Liquid chromatography (LC) is a separation technique in which the mobile phase is a liquid. Liquid chromatography can be carried out either in a column or a plane. Present day liquid chromatography that generally utilizes very small packing particles and a relatively high pressure is referred to as high performance liquid chromatography (HPLC).

The biggest difference between the two techniques is, as the name suggests, whether the sample is liquid or gas when it gets to the column. Due to this reason, liquid chromatography is often used when the sample cannot be volatilized to a gas to be analyzed by gas chromatography.

1 comment:

  1. Very good blogs posting…It will be very helpful for students and business people. Very good explanation on gas chromatography and liquid chromatography is provided. Thanks for the post and looking forward to such useful information. A couple of month I read about gas chromatography on chemtrol. They are manufactures of all oil and gas equipments.